The story of musician Dewey Cox (John C. Reilly), whose songs would change a nation. On his rock ‘n roll spiral, Cox sleeps with 411 women, marries 3 times, has 22 kids and 14 stepkids, stars in his own 70s TV show, collects friends ranging from Elvis to The Beatles to a chimp, and gets addicted to – and then kicks – every drug known to man… but despite it all, Cox grows into a national icon and eventually earns the love of a good woman – longtime backup singer Darlene (Jenna Fischer). The tongue-in-cheek references in this fake biopic were drawn from a variety of sources. Apatow and Kasdan noted that they watched various types of biopics for inspiration including those of Jimi Hendrix and Marilyn Monroe.

Cast:John C. Reilly as Dewey Cox Jenna Fischer as Darlene Cox Kristen Wiig as Edith Cox Angela Little Mackenzie as Beth Anne Matt Besser as Dave Tim Meadows Raymond J. Barry David Krumholtz David Koechner Chris Parnell Harold Ramis as Record Company Executive Jonah Hill as Dewey’s Brother Ed Helms Morgan Fairchild Eddie Vedder as Himself Jack White as Elvis Presley Paul Rudd as John Lennon Jack Black as Paul McCartney Jason Schwartzman as Ringo Starr Justin Long as George Harrison Adam Herschman as Jerry Garcia Skyler Gisondo as Dewey Jr. Frankie Muniz as Buddy Holly Will Ferrell as Neil Diamond (Rumored) Jacques Slade as Little Nuttzak